Latin name: zhenale
ATX code: G03XB01
Active substance: mifepristone
Manufacturer: Izvarino Pharma LLC, Russia
Conditions for dispensing from a pharmacy: On prescription
Zhenale is a birth control pill that causes bleeding soon after taking it. This is an emergency contraception, the use of which is intended to quickly prevent possible pregnancy.
Indications for use
Contraception is taken to prevent conception after unprotected sex or when another contraceptive method has proven unreliable. Zhenale tablets are not suitable for abortion. Birth control pills must be taken within 72 hours (three days) of the last unsafe sexual intercourse.
Composition of the drug
The tablets contain the active ingredient mifepristone in an amount of 10 mg per tablet. Additionally, the medication contains the following excipients: povidone, lactose monohydrate, magnesium stearate and potato starch.
Medicinal properties
How does the medicine work?
The active substance based on mifepristone has a contraceptive and antigestagenic effect. Mifepristone is a synthetic steroid hormone whose mechanism of action is antiglucocorticoid activity via a competitive mechanism. The effectiveness of the drug depends on the specific phase of the cycle when the woman took the pill. Thanks to the medication, the contractility of the myometrium is effectively increased, interleukin-8 is released in the choriodecidual cells.
Sensitivity to prostaglandins also decreases. Because of this, the fertilized egg does not attach to the wall of the uterus, if conception occurs, ovulation does not occur, and the endometrium becomes thinner. After oral administration, the drug is absorbed by 70% and reaches peak concentration in the blood after an hour and a half. The half-life averages 17 hours. It is completely eliminated from the body within three days.
Release forms
The average cost of medicine in Russia is 290 rubles per package.
The instructions indicate that the drug looks like tablets that are round and convex on both sides. One package contains 1 or 2 pieces, color – yellow-green. Can be sold in packs or jars.
Mode of application
How to take the medicine:
The product can be drunk 2 hours after meals or before, since food in the stomach impairs the absorption of the active substance. Before using the tablets, you should consult a gynecologist to understand whether mifepristone will help in a particular case, namely, to get your period after taking it. To ensure the effect of the medicine, it must be taken within three days after unprotected sex.
How long does it take for the medicine to start working?
The drug begins to act approximately 2 hours after administration, and over time, a possible interruption of conception occurs. If the drug was taken during ovulation or in the first phase of the cycle, then there may be a delay after pregnancy. In the second phase, rapid menstruation often occurs. Pregnancy after zhenale most often occurs in obese women and in those who took the required dosage late.
Genale or escapelle?
Escapelle consists of synthetic progestogens. It should be taken no later than 1-2 days after completion of sexual intercourse. There may be a negative consequence from use - the woman will become pregnant ectopically. Such a pregnancy must be terminated as early as possible, otherwise it is possible to rupture the ovary, and the fetus will not survive 100% in any case. Which is better to choose? The first drug is recommended.
Genale or postinor?
Postinor consists of levonogestrel, a synthetic progestin. In order for the drug to work well after some time, you should have as little body weight as possible, that is, it may not help large women. There is always one negative effect - after postinor, daubing begins. This is bleeding that resembles menstruation. Such unpleasant consequences are fraught with severe bleeding, which will begin suddenly and with severe pain.
Gynepriston or Zhenale?
Gynepristone has the same active ingredient - mifepristone, so these are two identical analogues. Does gynepristone help or not and which one can be considered the best? The remedies work the same way, but only a doctor prescribes medications.
During pregnancy and breastfeeding
If a woman becomes pregnant and her period does not come, then she can take mifepristone for a medical abortion for 3-4 weeks after the start of the delay. This procedure cannot be carried out independently; the dosage is prescribed by the doctor. If bleeding begins, then after 1.5 - 2 days, prostaglandin-based drugs are prescribed. After 1-2 months of pregnancy, a vacuum or surgical abortion is performed.
Contraindications
Porphyria, liver and kidney diseases, impaired homeostasis, anemia, impaired adrenal function, allergic reaction, desired pregnancy and lactation.
Precautionary measures
Cross-drug interactions
Genale and alcohol
It is not recommended to mix alcohol with medicine, otherwise the side effects may worsen; alcohol itself negatively affects the effectiveness of the medicine. Also, do not inject non-steroidal painkillers for 12 hours after taking the drug.
Side effects
Migraine, dizziness, allergic rash, loss of performance, diarrhea and vomiting, pain in the lower abdomen, spotting, increased body temperature.
Overdose
Hypofunction of the adrenal glands is possible.
Conditions and shelf life
Up to three years in a dry and cool place.
Analogs
CJSC "Obninsk Chemical Pharmaceutical Company", Russia
average price– 2100 rubles per package.
Miropriston is a complete analogue of the active substance, but with a difference in concentration. One tablet contains 200 mg of mifepristone. Only 3 tablets per pack. Miropriston is needed for medical abortion.
Pros:
- Efficiency
- Convenient release form.
Minuses:
- Expensive
- Causes severe discomfort.
Gedeon Richter, Hungary
average price in Russia – 390 rubles per package.
Postinor contains a synthetic gestagen in large quantities - levonorgestrel, which causes a sudden disruption of the cycle in order to prevent conception. The pack contains 2 tablets of 750 mg each, which should be taken as quickly as possible.
Pros:
- Helps
- Relatively inexpensive.
Minuses:
- Severely disrupts the cycle
- Causes bleeding.
If a young couple does not plan to have children in the near future, then they use contraception, fortunately, the range of them today is quite wide. In the arsenal of lovers there are condoms, spirals, patches and oral contraceptives - pills. But what if the unprotected event did take place? In an emergency situation, those created specifically for this will help.
When you need to act urgently
This kind of medication is used between 24 and 72 hours after sexual intercourse. Indications for the use of emergency pregnancy prevention methods are:
- unprotected sexual intercourse;
- condom rupture;
- problems with the intrauterine device;
- skipping 3 or more oral contraceptive tablets;
- rape;
- the very beginning of sexual activity.
One of the methods of force majeure contraception is the drug “Zhenale”. Instructions, reviews from doctors and buyers, as well as comparisons with similar medications are presented in our article.
Release form and description of the medication
This drug is produced in rather large round tablets, 1 piece in a package, tablet weight 10 mg, its color is light yellow, with a slight greenish tint. The above remedy should be taken orally two hours before meals or two hours after meals. The sooner a woman takes the drug after unprotected sexual intercourse, the faster and more effectively it will act. If vomiting occurs within 3 hours after taking the medicine, you should consult a doctor - this means that this particular medicine is not suitable for you, and you need to find a remedy with a similar effect as quickly as possible.
Contraindications and unwanted effects
Side effects are possible after taking Zhenale. They depend on personal intolerance to the components of the drug. This may include nausea, vomiting or headache. There is no need to worry about this, since such symptoms are possible after using any drug. Discharge after “Zhenale” is also possible, it can be bloody or colorless, this is a variant of the norm. Like any medicine, postcoital contraceptives have contraindications. These include kidney failure, low hemoglobin, pregnancy and lactation.
Please note that emergency contraception "Zhenale" does not protect against sexually transmitted diseases and AIDS; its effect is only aimed at preventing unplanned pregnancy. The above-mentioned drug cannot be used instead of regular contraception or after each individual sexual intercourse. It is not suitable for daily use as it is designed for emergencies. For permanent contraception, it is necessary to select regular oral contraceptives, which are taken orally every day at the same time.
The use of the Zhenale contraceptive is required only in the absence of pregnancy, since it does not cause abortion and will not get rid of an existing pregnancy, but it may well cause harm to the fetus. If, after taking the above-mentioned drug, fertilization does occur, medical or surgical termination of pregnancy is recommended. If a woman decides to keep the child, the risk of pathologies in the development of the unborn baby cannot be excluded.
The influence of "Zhenale" on women's health
This drug is a non-hormonal drug, so it does not affect a woman’s hormonal levels and does not disrupt the menstrual cycle. Menstruation after “Zhenale” comes on time, if the cycle is already established, the above-mentioned remedy does not cause any unpleasant sensations. While taking medications, drinking alcoholic beverages in large doses is prohibited. Of course, we cannot say that Genale and alcohol are categorically incompatible. Alcohol does not affect the effectiveness of this postcoital contraceptive, but you should still not combine the drug with it. The medicine discussed in the article has gained a good reputation among consumers - read about this below.
"Zhenale" - review and opinions about the drug
Women who have tried this means of express contraception note its high efficiency and lack of harm to the body, since it does not contain a lethal dose of hormones, but only one antihormone, which blocks the activity of sperm and prevents pregnancy. After taking Zhenale, many women were pleasantly surprised by the absence of unpleasant, and even painful, sensations after taking the pill. Many emergency contraceptives are difficult to tolerate by the body and cause a lot of inconvenience and side effects. After taking this drug there were no such troubles.
Consumers speak well of Zhenal also because it is not in short supply and can be easily purchased at almost any pharmacy. A doctor's prescription is not required for this, although it is advisable to consult a gynecologist before using it. This product costs about 300 rubles. An undoubted advantage is that periods after “Zhenale” come on time, at most they can be delayed for a couple of days, but this happens quite rarely. This means that the cycle does not break down, which cannot but please customers. Particularly thrifty consumers keep this product in their home medicine cabinet “just in case.”
Girls who have experienced the effects of the drug “Zhenale” usually leave positive reviews. Many people are surprised how gently it acts and does not affect weight. But before taking the pill, it is advisable to do a pregnancy test, since those who have regular sexual intercourse could “accidentally” become pregnant earlier, and in this case the drug will cause great harm to the fetus. This information is for those who still decide to keep the child.
Pregnancy and "Genale"
Those who are planning a pregnancy in the near future need to wait 2-3 weeks after “Zhenale” and then begin active actions. During the specified time, the drug is completely eliminated from the body and the health of the mother and the unborn baby is no longer threatened. This product has passed all clinical trials. And although the instructions indicate possible side effects and discomfort, in fact, a very small percentage of women feel unwell after taking the pill. Doctors also recommend “Zhenale” in emergency cases: the reviews of gynecologists about it inspire confidence. Doctors note that this product was created taking into account the characteristics of the female body, it does not disrupt the hormonal levels of patients.
A very important fact is that menstruation after “Zhenale” begins on time, according to the usual schedule. Naturally, the above-mentioned drug cannot be abused; it is recommended only in emergency cases, in particular, after unprotected sexual intercourse. The main component of "Zhenale" is mifepristone (of course, not only it, but in combination with other ingredients). It is usually used when necessary, and in doses much larger than one tablet. But to protect against unwanted pregnancy, 10 mg of the drug is quite enough.
It has already been mentioned that the delay after “Zhenale” is an extremely rare phenomenon, a maximum of a couple of days, and after this time the cycle is established. Gynecologists unanimously declare that the above-mentioned emergency contraception is the most effective. It was invented recently, therefore it includes all the latest developments in pharmacology and medicine. The effectiveness of Zhenale has been clinically proven, and women who have used this remedy claim that it is the best among similar medications.
Drugs with similar effects
Since “Zhenale” was created quite recently, it is worth mentioning the post-coital means that girls used before the above-mentioned contraceptive appeared on the market. Previously, medications such as Escapelle, Postinor or Gynepristone were used to protect against unwanted pregnancy. Let's look at them in more detail and compare the effectiveness of these funds with Zhenale.
Until recently, “Escapel” was the latest development by scientists in the field of express contraception, and was used when conventional methods of protection against unwanted pregnancy were not suitable or failed. The main component of the drug, levonorgestrel, is also used in Postinor. The advantage of this medicine and its main difference from its analogues is that it can be used even during breastfeeding, which means that it also acts gently and gently, like Zhenale. If pregnancy has already occurred, then “Escapelle” will not harm the fetus, that is, the baby will be born healthy. The effectiveness of this drug is as high as the previous one: all women who used this remedy avoided pregnancy.
Among the side effects of Escapelle, the most frequently mentioned are disruptions and irregularities of the menstrual cycle, heavy discharge, pain in the lower abdomen, and with them nausea and migraines. Few people have experienced any discomfort when taking this drug. Women also mentioned an allergic reaction to this medicine - redness and rashes on the skin, nausea, general weakness of the body, upset stomach, lethargy and drowsiness. But almost all customers were satisfied with the effect of the product, since it perfectly protected against the consequences of unprotected sexual intercourse. Russian scientists and gynecologists confirm the effectiveness of the drug, it is 97%. But do not forget that the product does not protect against sexually transmitted infections.
How the drug "Escapelle" works, dosage, indications and contraindications for use
The principle of operation of Escapelle is that it slows down the ovulation process and prevents the egg from leaving the ovary for fertilization. And if this has already happened, then this remedy prevents the fertilized egg from entering the uterus. The main condition is to take the pill no later than three days after sexual intercourse. If pregnancy occurs earlier, everything is meaningless. It is not recommended to take this drug constantly, since a large amount of hormones will harm the body, increase the number of side effects and reduce the activity of its action. There are no age restrictions for using Escapelle; you can take it from the beginning of sexual activity, but before that it is recommended to consult a gynecologist. In addition, to purchase the drug you need a doctor's prescription. This medicine is also available in 1 tablet per package. Contraindications to the use of "Escapel" may be:
- intolerance to the components of the drug;
- liver or kidney failure;
- pregnancy.
Very often, taking the pill is accompanied by discharge and bleeding from the genital tract, you should not be afraid of this, this is the norm. It is also advisable to take a pregnancy test before taking the medicine. This contraceptive is taken orally and should be taken with a sufficient amount of water. If vomiting begins within two to three hours after taking it, it is recommended to take another tablet to enhance the effect. And before the onset of the next menstruation, it is necessary to use local contraceptive methods, for example, a condom, since frequent use of the above-mentioned medicine increases the amount of discharge.
Comparison of the drugs discussed in the article
Since both “Zhenale” and “Escapelle” are similar express contraceptives, each woman herself or after consulting with a doctor must decide which method she will take. Another representative of the line of contraceptive drugs is Postinor. It has been known for a long time and has been sold for several decades, until recently being practically the only remedy that protected against unwanted pregnancy after unprotected sexual intercourse. The effectiveness of Postinor is only 85%, previously this was enough, but in comparison with previous means of emergency contraception, it is clear that it is inferior to its analogues. Modern similar drugs are more effective. "Postinor" is produced in a package of 2 tablets. Like the above medications, it must be taken orally, one tablet in the first 72 hours after intimacy, and the second after 12 hours after consuming the first.
The sooner a woman takes the drug after unprotected sex, the greater its effectiveness. The Postinora tablet contains a large concentration of hormones, so taking such a contraceptive is a kind of stress for the female body. Just like similar medications, you should not take Postinor too often, and after use you must use barrier contraception.
A large amount of hormones (with frequent use of the medicine) can weaken the body and disrupt the menstrual cycle. An allergic reaction in the form of a rash, as well as swelling, nausea and vomiting, pain in the lower abdomen, fatigue and lethargy, is possible to the above-mentioned contraceptive. Many women noted a sharp deterioration in their health and general condition after taking the pills. The effect of this medication is accompanied by heavy bleeding from the genitals. After taking Postinor, it is recommended to consult a gynecologist and carefully follow his recommendations.
Since Postinor is an analogue of Zhenale, the actions of both drugs are approximately similar, they pursue the same goal, but achieve it in different ways. Women who, due to circumstances, were forced to use emergency contraceptives, when choosing drugs (“Zhenale” or “Postinor”), preferred the first one. Almost all customers note that “Zhenale” acts more gently, does not cause painful or unpleasant sensations, and most importantly, does not disrupt the menstrual cycle. And after “Postinor”, menstruation comes either earlier or later than the due date, and is accompanied by pain in the lower abdomen and heavy discharge. Most customers complain of a sharp deterioration in their health after taking Postinor.
It is worth noting that the prices for these contraceptives are approximately the same. When choosing, it is worth considering that an unplanned pregnancy after Zhenale can occur with a very low probability, and it is much easier to tolerate.
Other emergency contraceptives
When talking about postcoital methods of preventing pregnancy, one cannot fail to mention the drug Ginepristone. Recommendations for the use of this medication, as well as the three previous ones, are the need for emergency contraception if there has been sexual intercourse without protection or a condom has failed. The essence of its action is that, due to the high concentration of hormones, the drug blocks ovulation and prevents sperm from fertilizing the egg. It also has contraindications, they are:
- renal failure;
- bronchial asthma;
- lung diseases;
- heart failure;
- pregnancy;
- lactation.
This drug, just like Escapelle and Postinor, has unpleasant side effects, including discomfort in the lower abdomen, nausea, vomiting, upset stomach, dizziness, allergies and skin rashes, weakness and drowsiness, as well as menstrual irregularities, abundant scarlet discharge from the genital tract.
Almost all emergency contraceptives have the same method of use, be it Zhenale or Gynepristone. The latter must be consumed orally no later than 72 hours after unprotected sexual intercourse. It is recommended to take the tablet with water and then not eat for two hours. This medicine is produced in 1 tablet per package, the drug costs 200-250 rubles. Dispensed with a doctor's prescription. Just like about the drug “Zhenale”, consumer reviews of “Ginepristone” are positive, but still the side effects and discomfort from the last means of contraception persuade women to choose “Zhenale”.
How to make the final choice
From our article you learned everything about the drug “Zhenale”: reviews from doctors and consumers about it, indications for use - and also received clear data comparing this means of post-coital contraception with other similar medications. Based on a detailed description of four similar drugs, we can conclude that of all the above contraceptives, Zhenale is the undoubted leader.
It has more advantages: no pain or discomfort after taking the pill, no heavy discharge, which also brings a lot of inconvenience. Although, in principle, all four contraceptives cope well with the task: the effectiveness of Postinor is 85%, Escapel is 97%, Ginepristone is also 97%, and the effectiveness of Zhenale is as much as 99%. And if science knows cases where, after taking the Postinor pill, a woman still became pregnant, then after using Zhenale, the likelihood of such surprises is practically reduced to zero.
Which of the above-mentioned drugs to choose is determined by each woman herself. This depends on personal tolerance to the components of the drug, on the health and age of the patient, and on the advice of the gynecologist. The main thing is that before taking emergency contraceptives, you need to consult with your doctor, since each of these drugs is a powerful drug, and taking one pill is still stressful for the body. Before and after using such a medicine, a woman is advised to listen to her own feelings and observe how she is feeling, paying attention to possible changes.
We hope our article will help you make a choice between the drugs “Escapelle” or “Zhenale”, as well as other similar ones. And finally: it is better to avoid unprotected sexual intercourse, use condoms or other barriers, and do not miss taking oral contraceptives on time, then you simply will not need post-coital contraception.
Excipients: lactose monohydrate - 123.4 mg, potato starch - 22 mg, K25 - 6 mg, sodium carboxymethyl starch - 5 mg, magnesium stearate - 1.6 mg.
1 PC. - contour cellular packaging (1) - cardboard packs.
1 PC. - contour cell packaging (2) - cardboard packs.
1 PC. - orange glass jars (1) - cardboard packs.
2 pcs. - orange glass jars (1) - cardboard packs.
pharmachologic effect
Synthetic steroidal antiprogestogen drug. It blocks the action at the receptor level and does not have gestagenic activity. Antagonism with GCS due to competition at the level of communication with receptors was noted.
Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.
Pharmacokinetics
Suction and distribution
After a single oral dose, Cmax is reached after 1.3 hours. Absolute bioavailability is 69%. In the blood, mifepristone is 98% bound to proteins: albumin and acidic α1-glycoprotein.
Removal
After the distribution phase, excretion occurs slowly at first, the concentration decreases by half between 12-72 hours, then more quickly. T 1/2 is 18 hours.
Indications
- emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).
Contraindications
- acute or chronic renal and/or liver failure;
- long-term therapy with glucocorticosteroids;
- porphyria;
- anemia;
— hemostasis disorders (including previous treatment);
- presence of severe extragenital pathology;
- adrenal insufficiency;
- pregnancy;
- lactation period;
- a history of hypersensitivity to mifepristone and/or auxiliary components.
Dosage
You should take 1 tablet. orally 2 hours before or 2 hours after a meal (in the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle.
Side effects
From the reproductive system: bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.
From the digestive system: nausea, vomiting, diarrhea.
From the side of the central nervous system:, dizziness.
Others: weakness, hyperthermia, urticaria.
Overdose
In cases of drug overdose, adrenal insufficiency may occur.
Drug interactions
The use of NSAIDs should be avoided for 8-12 days after taking the drug.
special instructions
The drug does not protect against sexually transmitted diseases and AIDS.
After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.
A 10 mg dose of the drug is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it medically or surgically. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.
Zhenale is a drug that belongs to the group of emergency (postcoital) contraception. The action of the drug is aimed at preventing unwanted pregnancy and can be compared to a “micro-abortion”. Like all drugs in this group, Zhenale is fraught with a hidden threat, so it should be taken only on the recommendation of your treating specialist.
In what situations should you use emergency contraception? This:
1. Unprotected sexual intercourse occurred.
2. In case of violent acts.
3. Coitus interruptus was performed incorrectly.
4. During sexual intercourse, the condom breaks or slips off.
5. Other situations of a similar nature.
But if this happens, and you independently “prescribed” Zhenale for yourself, no matter how much you want, you will have to go to the doctor. First, additional treatment may be needed to protect against the effects of the drug. Secondly, if sexual intercourse took place without the use of local contraception, then infection with sexually transmitted infections is possible, and it is better to treat them at the initial stage.
Zhenale instructions for use
Description: Zhenale is an antigestagenic drug. Postcoital contraceptive drug for oral administration.
Composition and release form.
The tablets are light yellow with a greenish tint, round, biconvex. One tablet contains mifepristone - 10 mg. Excipients: lactose monohydrate - 123.4 mg, potato starch - 22 mg, povidone K25 - 6 mg, sodium carboxymethyl starch - 5 mg, magnesium stearate - 1.6 mg.
Pharmachologic effect.
Zhenale is a synthetic steroidal antiprogestogen drug. It blocks the action of progesterone at the receptor level and does not have gestagenic activity. Antagonism with GCS due to competition at the level of communication with receptors was noted.
Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.
Pharmacokinetics.
Absorption and distribution. After a single oral dose, Cmax is reached after 1.3 hours. Absolute bioavailability is 69%. In blood plasma, mifepristone is 98% bound to proteins: albumin and acidic α1-glycoprotein.
Excretion.
After the distribution phase, excretion occurs slowly at first, the concentration decreases by half between 12-72 hours, then more quickly. T1/2 is 18 hours.
Indications for use.
Zhenale - emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).
Method of administration and dose.
Zhenale take 1 tablet orally 2 hours before or 2 hours after a meal (in the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle. The sooner you take Zhenale after unprotected intercourse, the more effective it will be. Contact your gynecologist if you vomit within 3 hours after taking Zhenale.
Side effect
When using Zhenale, the following side effects may occur.
From the reproductive system: bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.
From the digestive system: nausea, vomiting, diarrhea.
From the central nervous system: headache, migraine, decreased mood.
Other: weakness, hyperthermia, urticaria.
Genale contraindications:
- acute or chronic renal and/or liver failure; - long-term therapy with glucocorticosteroids;
- porphyria;
- anemia;
- hemostasis disorders (including previous treatment with anticoagulants);
- presence of severe extragenital pathology;
- adrenal insufficiency;
- pregnancy;
- lactation period;
- a history of hypersensitivity to mifepristone and/or auxiliary components.
Use during pregnancy and breastfeeding.
Zhenale should not be used during pregnancy. Breastfeeding should be stopped for 14 days after taking the drug.
Special instructions.
Zhenale does not protect against sexually transmitted diseases and AIDS. It is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, or monthly. After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.
A 10 mg dose of Genale is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it with medication or surgery. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.
There was no effect on the ability to drive vehicles and operate machinery.
Overdose.
In cases of drug overdose, adrenal insufficiency may occur.
Drug interactions.
The use of NSAIDs should be avoided for 8-12 days after taking the drug.
Storage conditions and periods.
Zhenale should be stored in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C.
Shelf life: 3 years.
